PUBLIKACJE NAUKOWE

Publikacje naukowe 2011

 

1. Zdzisław Chilmonczyk, Jerzy Kossakowski, Jarosław Walory, Mirosława Koronkiewicz, Ingebrigt Sylte, Gabriel Nowak, Andrzej J. Bojarski:

Influence of new high affinity serotonin transporter ligands on cellular cAMP levels.

Pharmacological Reports, 2011, 63, 560-588

2. Barbara Mirosław, Daniel Szulczyk, Anna E. Kozioł and Marta Struga:

4-(3-Fluorophenyl)-1-(propan-2-ylidene)thiosemicarbazone.

Acta Crystallographica Section E, Structure Reports Online , 2011, E67, o3010

3. Anna Bielenica, Jerzy Kossakowski, Marta Struga, Izabela Dybała, Paolo La Colla, Elena Tamburini, Roberta Lodo:

Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents.

Med. Chem. Res. 2011,  20, 1411-1420

4. Anna Bielenica, Jerzy Kossakowski, Marta Struga, Izabela Dybała, Roberta Loddo, Cristina Ibba, Paolo La Colla:

Synthesis and biological evaluation of new 3-phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones.

Sci Pharm, 2011; 79: 225-238

5. Michał Dobrowolski, Marta Struga, Daniel Szulczyk:

6-Bromo-2-methylsulfanyl-1,3-benzothiazole.

Acta Crystallographica Section E   (2011).E67, o3446-o3447  - Structure Reports Online.

 

 

Publikacje naukowe 2010


 

1.  Marta Struga,  Barbara Mirosław, Magdalena  Pakosińska-Parys, Aleksandra Drzewiecka, Piotr Borowski, Jerzy Kossakowski, Anna E. Kozioł:Synthesis, characterization and  supramolecular  synthons in crystals of new derivatives of 10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione.

Journal of Molecular Structure  965 (2010); 23-30

2. Marta Struga,   Szymon Rosołowski, Jerzy Kossakowski, Joanna Stefańska:

Synthesis and microbiological activity of thiourea derivatives of 4-azatricyclo[5.2.2.02,6]undec-8--ene-3,5-dione.

Archives of  Pharmacal Research  Vol 33. No 1, 47-54(2010)

3. Anna Bielenica, Jerzy Kossakowski:

Zastosowanie metod obliczeniowych do wyznaczania budowy modeli farmakoforowych receptorów 5-HT1A, 5-HT2A, oraz 5-HT7.

Biuletyn Wydziału Farmaceutycznego  Warszawskiego Uniwersytetu Medycznego No 1,  1-12(2010)

4. Anna Bielenica, Jerzy Kossakowski:

Modele oddziaływań ligandów arylopiperazynylowych z receptorami serotoninowymi 5-HT1A, 5-HT2A i 5-HT7.

Biuletyn Wydziału Farmaceutycznego  Warszawskiego Uniwersytetu Medycznego No 2,  13-21(2010)

5. Anna Bielenica, Jerzy Kossakowski:

9-Methyl-3,5-dioxo-4-azatricyclo[5.2.2.02,6]undec-8-ene-1,8-diyl diacetate.

Molbank 2010, M685, 1-4

6. Hema Tresa Varghese, C.Yohannan Panicker, K. madhusoodanan Pillai, Mary Y. Sheena, K. Raju, T.K. Manojkumar, Anna Bielenica, Christian van Alsenoy:

Spectroscopic investigations and computational  study of 4-(3-bromopropyl)-4-azatricyclo[55.2.2.02,6]undecane-3,5,8-trione.

Spectrochimica Acta Part A 76(2010), 513-522

7. C. Yohannan Panicker, Hema Tresa Varghese, K. Madhusoodanan Pillai, Y. Sheena Mary, K. Raju,T.K. Manojkumaar, Anna Bielenica, Christian Van Alsenoy:

Quantum chemical DFT study of 4-azatricyclo[5..2.2.02,6]undecane-3,5,8-trione.

Spectrochimica Acta Part A 75(2010), 1559-1565

8. Joanna Stefańska, Anna Bielenica, Marta Struga, Stefan Tyski, Jerzy Kossakowski,, Paolo La Colla, Elena Tamburini, Roberta Loddo:

Antimicrobial activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives.

Ann Microbiol 60(2010),  151-155

9. Jerzy Kossakowski, Mariola Krawiecka, Bożena Kuran, Joanna Stefańska, Irena Wolska:

Synthesis and preliminary evaluation of the antimicrobial activity of selected 3-benzofurancarboxylic acid derivatives.

Molecules  15(2010), 4737-4749

10. Magdalena Pakosińska-Parys, Jerzy Kossakowski  and Marta Struga:

1-Acetyl-17-{2-hydroxy-3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}-17-azapentacyclo[6.6.5.02,7.09,14.015,19]nonadeca-2,4,6,9,11,13-hexaene-16,18-dione.

Molbank 2010, M697; 1-4


 

 Publikacje naukowe 2009 

 

1. A.J.Bojarski; Bożena Kuran; Jerzy Kossakowski;   A.E. Kozioł; Ewa Jagiełło-Wójtowicz; Anna Chodkowska: Synthesis  and serotonin receptor activity of the arylpiperazine alkyl/propoxy derivatives of new azatricycloundecanes.

 European  Journal Medicinal Chemistry ; Vol 44; 2009(152-164)

 

2. Marta Struga; Jerzy Kossakowski; Barbara Mirosław; Anna E. Kozioł; Andrzej Zimniak:

 

Synthesis of new  1,3-Thiazepine derivatives.

 

Journal of  Heterocyclic Chemistry;   Vol 46;  2009 (298- 302)

 

3.  Joanna Stefańska; Anna Bielenica; Marta Struga; Stefan Tyski; Jerzy Kossakowski; Roberta Loddo; Cristina Ibba; David Collu; Esther Marongiu; Paolo La Colla:

 

Biological evaluation of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives.

 

Central European Journal of Biology; Vol 4(3); 2009(362-368)

 

4. Jerzy Kossakowski, Bożena Kuran, Mariola Krawiecka:

 

Synthesis of new n-substituted derivatives of 2-hydroxy-4,9-diphenyl-3a,4,9,9a-tetrahydro-1h-4,9-epoxybenzo[f]isoindole-1,3-dione and 2-hydroxy-5,8-dimethyl-3a,6,7,8,9,9b-hexahydro-4,9a-epoxybenzo[e]isoindole-1,3(4h)-dione with an expected anxiolytic activity.

 

Annales Universitatis Mariae Curie-Skłodowska  Lublin ; Sectio DDD; Vol. XXII, N 1,5 ;

 

31-37(2009)

 

5. Jerzy Kossakowski, Mariola Krawiecka, Bożena Kuran:

 

Synthesis of halogen derivatives of selected furobenzopiran-4-one and benzo[b]furan-2-carboxylic acid with an expected biological activity.

 

Annales Universitatis Mariae Curie-Skłodowska  Lublin ; Sectio DDD; Vol. XXII, N 1,6 ;

 

39-43(2009)

 

6. Jerzy Kossakowski, Kinga Ostrowska, Marta Struga, Joanna  Stefańska:

 

Synthesis of new derivatives of 2,2-dimethyl-2,3-dihydro-7-benzo[b]furanol with potential antimicrobial activity.

 

Medicinal Chemistry Research (2009) 18, 555-565

 

7. Marta Struga, Jerzy Kossakowski, Anna E.Kozioł, Ewa Kędzierska, Sylwia Fidecka, Paolo La Colla, Cristina Ibba, Gabriella Collu, Giuseppina Sanna, Barbara Secci, Roberta Loddo:

 

Synthesis , pharmacological and antiviral activity of 1,3-thiazepine derivatives

 

European Journal of Medicinal Chemistry      44(2009); 4960-4969

 

8. Jerzy Kossakowski, Magdalena Pakosińska-Parys, Marta Struga, Izabela Dybała, Anna E. Kozioł, Paolo La Colla, Laura Ester Marongiu, Cristina Ibba, David Collu and Roberta Loddo:

 

Synthesis and evaluation of in vitro biological activity of 4-substituted arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione.

 

Molecules 2009 14, 5189-5202

 

9.  Marta Struga, Jerzy Kossakowski, Anna E. Kozioł, Tadeusz Lis, Ewa Kędzierska, Sylwia Fidecka:

 

Synthesis and pharmacological activity of thiourea derivatives of 1,7,8,9-tetramethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione.

 

Letters in Drug Design & Discovery 2009; 6; 445-450

 

 Publikacje naukowe 2008 

1. M. Struga, J. Kossakowski, J. Stefańska, A. Zimniak, A.Kozioł: Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride.European Journal of Medicinal Chemistry, 43, 1309-1314 (2008) 

 

2. J. Kossakowski, B.Kuran: Synthesis of N-substituted derivatives of 8,11-dimethyl-3,5-dioxo-4azatricyclo[5.2.2.2.02,6]undec-8-en-1-yl acetate and screening of cytotoxic activity of selected azarticycloundecane compounds.Acta Poloniae Pharmaceutica-Drug Research, Vol. 65; No.3 ; 371-375 (2008)

 

3. J.Stefańska, M. Struga, S.Tyski, J. Kossakowski, M. Dobosz: Antimicrobial acivity of 2,4-dihydro-[1,2,4]triazol-3-one derivatives.Polish Journal of Microbiology, Vol. 57, No 2; 179-182 (2008)

 

4. J.Kossakowski, A. Bielenica, B.Mirosław, A.Kozioł, I. Dybała, M.Struga: 4-Azatricyclo[5.2.2.02,6]undecane –3,5,8-triones as potential pharmacological agents. Molecules 13,1570-1583 (2008) 

 

5. J.Kossakowski, A.Bielenica, M.Struga, A. E. Kozioł: Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[5.2.1.02.6]dec-8-ene-3,5-dione. MedicinalChemistry Research   Vol 17; 507-514 (2008)

 

6. J. Kossakowski, M. Pakosińska-Parys, M. Struga: Synthesis of oxiran –2-ylmethyl derivatives of 1-nitro-17-azapentacyclo[6.6.5.02,7.09,14.015,19]nonadec-2,4,6,9,11,13-heksaen-16,18-dione as potential beta-adrenolytics. Annales Universitatis Mariae Curie-Skłodowska Lublin-Polonia Sectio DDDVol.XXI, N 1, 3, 31-36 (2008)

 

7.  M. Struga; M. Krawiecka; J. Kossakowski; J.Stefanska; B.Mirosław; A.E. Kozioł:    Synthesis and structural characterisation of derivatives of tricyclo[2.5.1.02.6]dec-8-ene-3,5-dione with an expected antimicrobial activity.Journal of the Chinese Chemical Society; Vol.55(6);1258-1265 (2008)

 

8.  J. Kossakowski, K. Ostrowska, M. Struga, J. Stefańska: Synthesis of new derivatives of 2,2-dimethyl-2,3-dihydro-7-benzo[b]furanol with antimicrobial activity.Medicinal Chemistry Research DOI 10.1007/s00044-008-9149-5   (2008)

 

9. J. Kossakowski, M. Pakosińska-Parys, M.Struga: Synthesis of oxiran-2-ylmethyl derivatives of 1-nitro-17-azapentacyclo[6.6.5.02,7,09,14,015,19]nonadec-2,4,6,9,11,13-heksaen-16,18-dione as potential beta-adrenolytics. Annales Universitatis Mariae Curie-Skłodowska – Lublin Sectio DDDVol. XXI, N 1,3 (2008)

 

Publikacje naukowe 2007

 

 

1. M.Struga, B. Mirosław, I. Wawrzycka-Gorczyca, J. Kossakowski and A.E.Kozioł: Synthesis, molecular and crystal structure of two tricyclic N-aminoimides. Polish Journal Chemistry, 81, 51-59(2007)

 

2. Marta Struga, Jerzy Kossakowski, Ewa Kędzierska, Sylwia Fidecka and Joanna Stefańska: Synthesis and pharmacological activity of urea and thiourea derivatives of 4-azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione. Chemical and Pharmaceutical Bulletin, Vol.55; No.5; 796-799(2007)

 

3. Marta Struga, Jerzy Kossakowski, Barbara Mirosław, Anna E. Kozioł: Synthesis of N-acetyl-N-(3,5-dioxo-10-oxa-4-azatricyclo[5.2.1.02,6]dec-4-yl)-acetamide. Molbank 2007, M533

 

4. Marta Struga and Jerzy Kossakowski: Synthesis of 4-Amino-1,7,8,9-tetramethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione. Molbank 2007, M534

 

5. Jerzy Kossakowski, Marta Struga, Barbara Mirosław, Anna E.Kozioł: Synthesis of new derivatives of 4-amino-10-oxa-4-azatricyclo[5.2.1.02,6}dec-8-ene-3,5-dione. Annals of Polish Chemical Society 2007 Roczniki PTChem 2007; 565-568(2007)

 

6. Jerzy Kossakowski, Anna Wojciechowska, Izabela Dybała: Derivatives of 2,3-dihydro-5H-[1,4]dithiino[2,3-C]pyrrole-5,7(6H)-dione as potential anxiolytics. Annals of Polish Chemical Society 2007 Roczniki PTChem 2007; 249-252(2007)

 

7. Jerzy Kossakowski, Mariola Krawiecka, Bożena Kuran: Synthesis of aryl- and heteroarylpiperazinyl derivatives of azatricycloundecane system as potential 5-HT receptor ligands. Annals of Polish Chemical Society 2007 Roczniki PTChem 2007; 244-248(2007)

 

8. Jerzy Kossakowski, Magdalena Pakosińska-Parys: Arylpiperazinyl derivatives of cyclic imides containing the anthracene system as potential an anxiolytics. Annals of Polish Chemical Society 2007 Roczniki PTChem 2007; 240-243(2007)

 

9. Mariola Krawiecka, Irena Wawrzycka-Gorczyca, Agnieszka Gałązka, Jerzy Kossakowski and Anna E. Kozioł: 10,11-Dihydroxy-4-azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione. Acta Crystallographica Section E Structure Reports Online; E63; o3878 (2007)

 

10. Jerzy Kossakowski, Bożena Kuran: Synthesis of preliminary evaluation of aminoalkanol derivatives of selected azatricycloundecane system for binding with beta-adrenergic and 5HT1A and 5HT2A receptors. Acta Poloniae Pharmaceutica- Drug Research, Vol 64(6); 527-533(2007)

 

11. Marta Struga, Jerzy Kossakowski ; Synthesis of aminoalkanol derivatives of 4-hydroxy-1,7,8,9,10-pentamethyl-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione as potential beta-adrenolytics. Acta Poloniae Pharmaceutica- Drug Research, Vol 64(6); 523-526(2007)

 

Publikacje naukowe 2010